1cP-LSD and 1B-LSD: Differences & Similarities of the Two Substances
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Time to read 4 min
1Fe-LSD and 1SB-LSD belong to a newer generation of LSD derivatives that are controversially discussed, particularly in the context of research, legislation, and the psychonaut community.
Both compounds, like numerous previous LSD analogs, are based on the same lysergamide backbone but vary in their appended side groups. These structural modifications are presumed to affect both pharmacological properties and legal classification.
Initial anecdotal reports and theoretical considerations suggest that their onset of action and metabolism might differ slightly from LSD-25 and known LSD derivatives.
The following article's examination of similarities and differences aims to help objectively assess 1SB-LSD and 1Fe-LSD and differentiate between them.
Enjoy reading the blog post!
Note: 1SB-LSD and 1Fe-LSD are not intended for human consumption. All content described is based on scientific sources or subjective experience reports and should not be understood as instructions or recommendations.
Table of Contents:
1. The Cat-and-Mouse Game Surrounding LSD Derivatives 2. How do LSD Analogs Work? 3. LSD Derivatives from a Chemical Perspective 3.1 What is 1Fe-LSD from a Chemical Perspective? 3.2 What is 1SB-LSD from a Chemical Perspective? 4. Legal Considerations 4.1 The Legal Status of 1Fe-LSD 4.2 The Legal Status of 1SB-LSD 5. Conclusion: The Special Role of Research Chemicals
The Cat-and-Mouse Game Surrounding LSD Derivatives
With the introduction of the New Psychoactive Substances Act (NpSG) in 2016, German drug policy aimed to more effectively address the constant influx of new research chemicals. For this purpose, further substances and their modifications are continuously added to the relevant prohibition lists by regulation.
In practice, however, this approach by the Federal Ministry of Health to curb the consumption and abuse of psychoactive substances has developed into a veritable competition between legislators and the psychedelic scene.
In recent years, numerous LSD derivatives have already been banned, including 1D-LSD, 1V-LSD, 1T-LSD, 1cP-LSD, and 1SB-LSD. At the same time, each ban was usually followed relatively quickly by a new, legally permissible variant that again made handling LSD-like substances legal. This situation has continued for 10 years now.
How do LSD analogs work?
The effects of modern LSD derivatives such as 1Fe-LSD, 1BP-LSD, 1B-LSD, or 1SB-LSD are fundamentally similar to the effects of the prohibited drug lysergic acid diethylamide (LSD).
Legal LSD alternatives are specifically developed to function as so-called prodrugs in the organism. This means that they only unfold their actual effects after certain metabolic processes.
Specifically, this means that the respective LSD analog is gradually converted into classic LSD in the body and subsequently produces similar psychoactive effects. Due to additional molecular components that must first be cleaved off, the onset of action may be slightly delayed compared to LSD-25.
After metabolism, these derivatives interact with specific receptor systems in the brain. In particular, binding to the 5-HT2A serotonin receptor is considered a central trigger for the hallucinogenic effect, which, according to experience reports, can manifest as altered states of consciousness and changed perception.
In unfavorable cases, subjectively distressing, temporary experiences, often described by users as "bad trips," may also occur.
Chemical structural formula of LSD-25
LSD Derivatives from a Chemical Perspective
What is 1Fe-LSD from a chemical perspective?
The new research chemical 1Fe-LSD refers to the substance 1-(Ferrocencarbonyl)-LSD, an LSD prodrug that was introduced at the end of 2025 alongside 1BP-LSD as a successor to previously banned LSD analogs.
As with numerous previously available LSD analogs, 1Fe-LSD also features an additional side chain coupled to the core molecule via an amide bond. The novelty with 1Fe-LSD is the addition of the iron compound ferrocene to the indole ring, which is also likely responsible for the characteristic orange coloration of the blotters, pills, and pellets.
Chemical structural formula of 1Fe-LSD
What is 1SB-LSD from a Chemical Perspective?
1-(4-(trimethylsilyl)benzoyl)-LSD, also known as 1SB-LSD in its abbreviated form, is a modern research chemical.
As with many previously available LSD derivatives, 1SB-LSD also features an additional side chain linked to the core molecule via an amide bond on the indole ring. The peculiarity of this compound is the chemical composition of this modification: there is a 4-trimethylsilyl group on the benzyl ring.
Legal Considerations
The Legal Status of 1Fe-LSD
1Fe-LSD is, alongside 1BP-LSD, the most recent available LSD derivative. It was launched after the ban on 1S-LSD and 1SB-LSD was decided in November 2025 and is currently (as of 01/2026) legally available in Germany, as it does not fall under the New Psychoactive Substances Act (NpSG), nor the Medicines Act or the Narcotics Act (BtMG).
The Legal Status of 1SB-LSD
As already mentioned in the previous section, the substance 1SB-LSD was banned in Germany, along with 1S-LSD, through an amendment to the New Psychoactive Substances Act (NpSG) in November 2025. The final sales and distribution ban came into force in December 2025. Since then, both LSD analogs are no longer legally available on the market.
Conclusion: The Special Role of Research Chemicals
The emergence of research chemicals like 1P-LSD, 1SB-LSD, or 1Fe-LSD should be understood as a direct response to drug policy measures.
Their conception follows the "legal-by-design" principle, which means that when they are developed and produced, pharmacology or safety are not the main criteria; instead, the clear goal is to create a legal substance.
To continuously offer substances that do not fall under current prohibitions, the basic structure of a molecule is altered without significantly affecting its original effects. These very efforts have also led to the emergence of 1SB-LSD and 1Fe-LSD.
In this way, thanks to the efforts of various manufacturers, LSD derivatives such as 1Fe-LSD, 1BP-LSD, or 1SB-LSD are created, enabling those interested in psychonautics and other researchers to discover the hallucinogenic effects of psychedelics without having to acquire a prohibited drug and thus incur legal risks.
Sources
- Tanaka R., Kawamura M., Mizutani S., Kikura-Hanajiri R. (2023). Identification of LSD analogs, 1cP-AL-LAD, 1cP-MIPLA, 1V-LSD and LSZ in sheet products. Forensic Toxicol. 2023 Jul;41(2):294-303. doi: 10.1007/s11419-023-00661-1.
- Vargas M. V., Dunlap L. E., Dong C., et al. (2023). Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science. 2023 Feb 17;379(6633): 700-706. doi: 10.1126/science.adf0435.
- Brandt S. D., Kavanagh P. V., Gare S., Elliott S. P., Stratford A., Halberstadt A. L. (2025). Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD). Drug Test Analy. 2025 Aug;17(8): 1283-1293. doi: 10.1002/dta.3829.
Natascha
is a philologist and archaeologist, fascinated by how psychedelic substances have influenced human cultural history for centuries. Later, her path led her to study psychology, where her curiosity about the therapeutic possibilities of psychedelics grew even stronger. Today, she is particularly excited by the question of what potential these unique molecules hold for therapies, growth, self-development, and the evolution of our personalities.