1S-LSD and 1BP-LSD belong to a relatively new generation of LSD derivatives, which are primarily discussed in the context of research, the scene, legal gray areas, and new psychoactive substances.
Both compounds are based on the same lysergamide backbone but differ in chemical modification at the indole nitrogen. These structural differences have not only legal but also pharmacological and practical implications.
Experience reports and theoretical considerations suggest that their effects, stability, and conversion in the body may differ in nuances. A precise comparison of similarities and differences helps to objectively classify and differentiate 1S-LSD and 1BP-LSD.
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Note: 1S-LSD and 1BP-LSD are not intended for human consumption. All described content is based on scientific sources or subjective experience reports and should not be understood as instructions or recommendations.
Table of Contents:
1. The Cat-and-Mouse Game with LSD Analogs 2. The Legal Situation 2.1 The Legal Status of 1S-LSD 2.2 The Legal Status of 1BP-LSD 3. How Does an LSD Derivative Work? 4. LSD Derivatives from a Chemical Perspective 4.1 What is 1S-LSD from a Chemical Perspective? 4.2 What is 1BP-LSD from a Chemical Perspective? 5. Conclusion: Research Chemicals and Their Significance
The Cat-and-Mouse Game with LSD Analogs
Germany's drug policy, with the introduction of the New Psychoactive Substances Act (NpSG) in 2016, aimed to curb the spread of ever new research chemicals. For this purpose, more and more substances and substance variants are added to the list of prohibitions through regulations.
In fact, this attempt by the German Federal Ministry of Health to curb the abuse and consumption of drugs, research chemicals, and narcotics has developed into a race between psychedelic research and legislators.
Thus, numerous LSD derivatives have already been banned in the past, such as 1D-LSD, 1T-LSD, 1V-LSD, 1cP-LSD, and 1B-LSD. For each banned LSD variant, a new legal substance came onto the market, making derivative LSD consumption legal again.
The Legal Situation
The Legal Status of 1S-LSD
The latest amendment by the German federal government, enacted in the NpSG, concerned the prohibition of 1S- and 1SB-LSD in November 2025. Consequently, both substances are currently (12/2025) illegal in Germany.
The Legal Status of 1BP-LSD
1BP-LSD is currently the newest LSD derivative available on the market. It was released in response to the NpSG amendment passed in November 2025 and is currently (12/2025) legally available in Germany, as it is not covered by the New Psychoactive Substances Act (NpSG), the Narcotics Act (BtMG), or the Medicinal Products Act.
How Does an LSD Derivative Work?
The effects of LSD derivatives like 1BP-LSD, 1P-LSD, 1V-LSD, or 1S-LSD are essentially similar to the mechanisms of action of the parent substance lysergic acid diethylamide (LSD). Derivatives are designed by expert chemists to function as prodrugs of LSD.
This means that the LSD analog is metabolized in the body into LSD through various processes and essentially has the same effect. Due to additional side chains and atoms, the onset of the effect may be slightly delayed.
After metabolism, LSD derivatives bind to specific receptors in the brain. Their interaction with the 5-HT2A serotonin receptor produces the typical hallucinogenic intoxication, the so-called "trip," with alterations in consciousness and perception.
In the worst-case scenario, this can lead to unpleasant, temporary experiences, often referred to by users as a "bad trip".
LSD Derivatives from a Chemical Perspective
What is 1S-LSD from a Chemical Perspective?
1S- or 1-(3-(trimethylsilyl)propionyl)-LSD is a research chemical in which a small side chain, consisting of a trimethylsilyl-containing propionyl group, is attached to a nitrogen atom in the indole ring (N1).
This additional attachment ultimately forms the 1S-LSD molecule, which is chemically distinct from LSD but can be converted back into the known parent substance in the body.
Chemical structural formula of 1S-LSD
What is 1BP-LSD from a Chemical Perspective?
The novel research chemical 1BP-LSD refers to the substance (6aR,9R)-N,N-diethyl-7-methyl-4-(4-(4,4,5,5-tetraethyl-1,3,2-dioxaborolan-2-yl)benzoyl)-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide.
As with numerous previously available LSD analogs, the additional side chain in 1BP-LSD is also linked to the parent molecule via an amide bond. The peculiarity of this compound, however, lies in the chemical composition of this modification: a boron-containing heterocycle is located on the indole nitrogen. Thus, 1BP-LSD structurally differs from earlier derivatives due to the boron atom contained in the side chain.
Chemical structural formula of 1BP-LSD
Conclusion: Research Chemicals and their Significance
Research chemicals such as 1cP-LSD, 1SB-LSD or 1BP-LSD are a response to global drug policies. Their development follows the "legal-by-design" principle, which prioritizes the creation of a legal substance rather than pharmacological aspects in its manufacture.
In order to consistently develop a substance that bypasses current laws, the fundamental structure of a molecule is adapted without significantly altering its original effect — and this is how research chemicals like 1BP-LSD are created.
This ingenuity of chemists allows the psychonautic scene and other interested individuals to explore the psychedelic effects of hallucinogens without consuming an illegal drug.
Sources
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- Brandt S. D., Kavanagh P. V., Gare S., Elliott S. P., Stratford A., Halberstadt A. L. (2025). Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD). Drug Test Analy. 2025 Aug;17(8): 1283-1293. doi: 10.1002/dta.3829.
Natascha
is a philologist and archaeologist, fascinated by how psychedelic substances have influenced human cultural history for centuries. Later, her path led her to psychology studies, where her curiosity about the therapeutic possibilities of psychedelics grew even stronger. Today, she is particularly excited by the question of what potential these special molecules hold for therapy, growth, self-discovery, and the development of our personalities.